Title | Thrombolytic therapy for acute ischemic stroke beyond three hours. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Carpenter CR, Keim SM, Milne WKenneth, Meurer WJ, Barsan WG |
Corporate Authors | Best Evidence in Emergency Medicine Investigator Group |
Journal | J Emerg Med |
Volume | 40 |
Issue | 1 |
Pagination | 82-92 |
Date Published | 2011 Jan |
ISSN Number | 0736-4679 |
Keywords | Acute Disease, Adolescent, Adult, Aged, Brain Ischemia, Evidence-Based Medicine, Female, Humans, Middle Aged, Randomized Controlled Trials as Topic, Stroke, Thrombolytic Therapy, Time Factors, Tissue Plasminogen Activator, Treatment Outcome |
Abstract | <p><b>BACKGROUND: </b>Ischemic cerebrovascular accidents remain a leading cause of morbidity and mortality. Thrombolytic therapy for acute ischemic stroke within 3h of symptom onset of highly select patients has been advocated by some groups since 1995, but trials have yielded inconsistent outcomes. One recent trial demonstrated significant improvement when the therapeutic window was extended to 4.5h.</p> |
DOI | 10.1016/j.jemermed.2010.05.009 |
Alternate Journal | J Emerg Med |
PubMed ID | 20576390 |
PubMed Central ID | PMC3217216 |
Grant List | KM1 CA156708-01 / CA / NCI NIH HHS / United States |
Thrombolytic therapy for acute ischemic stroke beyond three hours.
Faculty Reference:
Samuel M. Keim, MD, MSc
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