| Title | Neuroprotection in acute brain injury: an up-to-date review. |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Stocchetti N, Taccone FS, Citerio G, Pepe PE, Le Roux PD, Oddo M, Polderman KH, Stevens RD, Barsan W, Maas AIR, Meyfroidt G, Bell MJ, Silbergleit R, Vespa PM, Faden AI, Helbok R, Tisherman S, Zanier ER, Valenzuela T, Wendon J, Menon DK, Vincent J-L |
| Journal | Crit Care |
| Volume | 19 |
| Pagination | 186 |
| Date Published | 2015 |
| ISSN Number | 1466-609X |
| Abstract | <p>Neuroprotective strategies that limit secondary tissue loss and/or improve functional outcomes have been identified in multiple animal models of ischemic, hemorrhagic, traumatic and nontraumatic cerebral lesions. However, use of these potential interventions in human randomized controlled studies has generally given disappointing results. In this paper, we summarize the current status in terms of neuroprotective strategies, both in the immediate and later stages of acute brain injury in adults. We also review potential new strategies and highlight areas for future research.</p> |
| DOI | 10.1186/s13054-015-0887-8 |
| Alternate Journal | Crit Care |
| PubMed ID | 25896893 |
| PubMed Central ID | PMC4404577 |
| Grant List | U01 NS081041 / NS / NINDS NIH HHS / United States |
Faculty Reference:
Terence Valenzuela, MD, MPH
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