| Title | Intentional use of carbapenem antibiotics for valproic acid toxicity: A case report. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Khobrani MA, Dudley SW, Huckleberry YC, Kopp BJ, Biggs AD, French RNE, Shirazi FM, Erstad BL |
| Journal | J Clin Pharm Ther |
| Volume | 43 |
| Issue | 5 |
| Pagination | 723-725 |
| Date Published | 2018 Oct |
| ISSN Number | 1365-2710 |
| Keywords | Anticonvulsants, Carbapenems, Drug Interactions, Humans, Male, Meropenem, Middle Aged, Valproic Acid |
| Abstract | WHAT IS KNOWN AND OBJECTIVE: The interaction between valproic acid (VPA) and carbapenem antibiotics is well described with previous reports suggesting a reduction in VPA half-life between 47% and 90%. As described in this case, this interaction might be beneficial in the setting of toxic VPA ingestion. CASE DESCRIPTION: An intubated, unresponsive patient arrived via emergency medical services after toxic VPA ingestion. Meropenem was prescribed for a suspected pneumonia and to take advantage of the VPA interaction. We observed a 56% decline in half-life with short-term meropenem dosing and an improvement in mental status shortly after administration. WHAT IS NEW AND CONCLUSION: Our findings suggest a potential role for short-term carbapenem therapy for VPA overdose. |
| DOI | 10.1111/jcpt.12705 |
| Alternate Journal | J Clin Pharm Ther |
| PubMed ID | 29733112 |
Intentional use of carbapenem antibiotics for valproic acid toxicity: A case report.
Faculty Reference:
Robert N.E. French, MD, MPH
Farshad "Mazda" Shirazi, MD, PhD, FACEP, FACMT
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