Implementation of the exception from informed consent regulations in a large multicenter emergency clinical trials network: the RAMPART experience.

TitleImplementation of the exception from informed consent regulations in a large multicenter emergency clinical trials network: the RAMPART experience.
Publication TypeJournal Article
Year of Publication2012
AuthorsSilbergleit R, Biros MH, Harney D, Dickert N, Baren J
Corporate AuthorsNETT Investigators
JournalAcad Emerg Med
Volume19
Issue4
Pagination448-54
Date Published2012 Apr
ISSN Number1553-2712
KeywordsBiomedical Research, Brain Diseases, Clinical Trials as Topic, Community-Institutional Relations, Emergency Medicine, Guideline Adherence, Guidelines as Topic, Humans, Informed Consent, Patient Selection, Risk Assessment, United States
Abstract

Clinical trials investigating therapies for acutely and critically ill and injured patients in the earliest phases of treatment often can only be performed under regulations allowing for exception from informed consent (EFIC) for emergency research. Implementation of these regulations in multicenter clinical trials involves special challenges and opportunities. The Rapid Anticonvulsant Medication Prior to Arrival Trial (RAMPART), the first EFIC trial conducted by the Neurological Emergencies Treatment Trials (NETT) network, combined centralized resources and coordination with retention of local control and flexibility to facilitate compliance with the EFIC regulations. Specific methods used by the NETT included common tools for community consultation and public disclosure, sharing of experiences and knowledge, and reporting of aggregate results. Tracking of community consultation and public disclosure activities and feedback facilitates empirical research on EFIC methods in the network and supports quality improvements for future NETT trials. The NETT model used in RAMPART demonstrates how EFIC may be effectively performed in established clinical trial networks.

DOI10.1111/j.1553-2712.2012.01328.x
Alternate JournalAcad Emerg Med
PubMed ID22506949
PubMed Central IDPMC3335290
Grant List5U01NS056975-04 / NS / NINDS NIH HHS / United States
U01 NS056975 / NS / NINDS NIH HHS / United States
U01 NS056975-06S1 / NS / NINDS NIH HHS / United States
UL1 RR025008 / RR / NCRR NIH HHS / United States