The Arizona Emergency Medicine Research Center (AEMRC) Phoenix is an internationally acclaimed hub for research focusing on improving outcomes for victims of time-sensitive cardiovascular, neurologic, and traumatic medical emergencies. The AEMRC brings together a strong team of seasoned, NIH-funded, prehospital researchers concentrating on measuring and improving the effectiveness of life-saving prehospital medical interventions. The team includes expertise in epidemiology, database integration, advanced biostatistics, and prehospital outcomes research under the direction of Drs. Dan Spaite and Ben Bobrow.
AEMRC Phoenix has partnered with the Arizona Department of Health Services to implement successful public health programs such as the Save Hearts in Arizona Registry & Education (SHARE) Program (www.azshare.gov). The SHARE Program has collected over 20,000 out-of-hospital cardiac arrest events from over 150 EMS agencies, 40 hospitals, and 9 emergency medical dispatch centers in Arizona. SHARE promotes a system of care approach for measuring and improving survival from cardiac arrest in Arizona. This methodology encompasses all "links" in the "chain of survival" – bystander response, emergency medical dispatcher CPR instruction, Emergency Medical Services provider resuscitation, and specialized hospital care along with continuous measurement and outcomes evaluation. This effort has made a significant difference in the survival rates of people who suffer cardiac arrest in Arizona, where there has been a tripling in neurologically intact survival since 2004. The AEMRC is a founding partner in the HeartRescue Project in the US and the HeartRescue-Global Project currently underway in China and India.
The AEMRC Phoenix has led the NIH-funded Excellence in Prehospital Injury Care (EPIC) Project which is a program to implement and measure the impact of the nationally vetted Traumatic Brain Injury Prehospital Guidelines. The EPIC Project is collecting comprehensive EMS and Trauma Center Data on more than 22,000 TBI patients in Arizona in a before/after comparison to evaluate the impact of the prehospital TBI guidelines on patient outcomes. More than 120 Arizona EMS agencies are participating in the project, and over 10,000 EMS providers have been trained in guideline-standard care.
The AEMRC has also been integral to The Ontario Prehospital ALS Study (OPALS), the RAMPART prehospital status epilepticus trial, the Institute of Medicine reports on the EMS Agenda for the Future and Treatment of Cardiac Arrest: Current Status and Future Directions, the NHTSA Uniform Data Consensus Conference, the EMS Research Agenda, the EMS Outcomes Project (EMSOP), the EMS Cost Analysis Project (EMSCAP), and the NHTSA-sponsored development of a national model for Evidence-Based Guidelines in EMS.
The AEMRC Phoenix has an active international EMS Scholar’s Program and has worked closely with both EMS professionals and EMS researchers in numerous countries around the world.
The AEMRC Phoenix is also active in clinical research in the Phoenix metropolitan area under the direction of Kurt Denninghoff, MD. Dr. Denninghoff leads a collaboration of Phoenix hospitals and EMS agencies to implement emergency neurological trials as one of 22 nationwide hubs in the NIH-funded Neurological Emergencies Treatment Trials (NETT) network. This clinical research focuses on traumatic brain injury, spinal cord injury, ischemic and hemorrhagic stroke, seizures, post-cardiac arrest neurological management and other time-sensitive major health problems in the prehospital and hospital settings.
Current studies include POINT (Platelet Oriented Inhibition in New TIA and minor acute stroke), ATACH II (Antihypertensive Treatment of Acute Cerebral Hemorrhage), SHINE (Stroke Hyperglycemic Insulin Network Effect) and ESETT (Established Status Epilepticus Treatment Trial). Studies in development include ARCTIC (Acute Rapid Cooling Therapy for Injuries of the Spinal Cord) and ICECAP (Influence of Cooling Duration on Efficacy in Cardiac Arrest patients).
Completed studies include ProTECT (Progesterone for Traumatic Brain Injury-Experimental Clinical Trial), BioProTECT (Biomarkers in TBI), ALIAS (Albumin in Acute Stroke), and RAMPART (Rapid Anticonvulsant Medication Prior to Arrival Trial).