The Southwest PECARN Research Node is made up of three partnered institutions: The University of Arizona, The University of New Mexico and the University of Oklahoma. There are certain PECARN research studies that are being done at each of these centers; and there are a few studies that are being implemented at only one or two of our networked Hospital Emergency Department Affiliates (HEDAs).
Current Research being done at all three institutions
PECARN Core Data Project (PCDP):
This project is a cross-sectional study of all pediatric ED visits from all sites within the network. A database of electronic administrative data is compiled annually from 2002 to the present. This study has several aims:
- to identify the frequency and type of PECARN Emergency Department (ED) visits;
- to identify the availability of data elements from existing electronic databases and chart reviews at each HEDA;
- to identify the availability of clinical parameters collected during usual medical care of patients with selected diagnoses (asthma and long bone fractures);
- to measure the agreement between, and completeness of, data elements collected by electronic methods and chart review.
This study provides important epidemiological information regarding pediatric emergency department visits in the PECARN network. Data are collected annually from all hospital sites.
Application of Transcriptional Signatures for Diagnosis of Febrile Infants within the PECARN Network (BioSigs):
The study investigators have identified novel and distinct RNA expression patterns (RNA biosignatures) in febrile infants ≤ 60 days of age. This proof-of-concept work has demonstrated well-defined RNA biosignatures in infants with bacterial and non-bacterial infections. Febrile infants with bacterial infections have distinct RNA gene expression patterns characterized by over-expression of inflammatory genes, while interferon genes are consistently over-expressed in febrile infants without bacterial infections. This previous work has identified 66 classifier genes that discriminate febrile infants with bacterial infections with 87% accuracy, suggesting a potentially more accurate reference than microbiologic cultures.
The long-term objective of this research protocol is to investigate whole genome RNA expression profiles to define RNA biosignatures that allow precise diagnosis of isolated bacterial infections, isolated viral infections and bacterial-viral co-infections in febrile infants ≤ 60 days of age. Addressing the optimal evaluation and management of the febrile infant will assure that this vulnerable population of children have the chance to achieve their full potential for healthy and productive lives, free from disease or disability.
Current Research being done at SW PECARN Node Hub: The University of Arizona, Arizona Emergency Medicine Research Center (AEMRC)
Several research proposals awaiting funding.
Current Research being done at the New Mexico HEDA: The University of New Mexico Health Sciences Center
Acute Gastroenteritis-Impact of Emergency Department Probiotic Treatment of Pediatric Gastroenteritis (Probiotics)
Acute gastroenteritis (AGE) is a leading cause of malnutrition and death worldwide and affects millions of children in the US each year. Most AGE is viral in origin, and apart from care focused on rehydration and nausea, there are no therapies to reduce the severity of illness. The overall objective of this randomized, placebo-controlled, double-blind, multi-center study is to determine the efficacy and side effect profile of the probiotic, Lactobacillus rhamnosus GG (LGG), in children aged 3 to 48 months presenting to the ED with AGE. Patients will be randomized to receive either LGG or placebo twice a day for 5 days, for a total of 10 doses. We plan to enroll 900 children in 9 PECARN sites over 4 years. This project is funded by the NICHD. http://probioticstudy.wustl.edu/
Current Research being done at the Oklahoma HEDA: Oklahoma University Health Science Center
Arginine Feasibility Project
The Arginine Feasibility project was funded as part of an R34 clinical trials planning grant that will establish a protocol steering committee with expertise in Sickle Cell Disease (SCD) clinical trials, create a clinical network of sites with a strong track record of successful participation in multi-center trials, create an ED-based pain protocol, develop a data coordinating plan, identify safety and clinical endpoints and a completed protocol for a phase III clinical trial of L-arginine for the treatment of vaso-occlusive pain in children with SCD to be submitted for NIH funding. Specifically this study is creating a standardized ED-based pain therapy protocol based on NIH guidelines that will be utilized in the future phase III trial, collecting feasibility data on volume, time of visit and admission rates from high-volume PECARN and non-PECARN sites on all potentially eligible patients with SCD and collecting demographic and clinical data through a 20 patient chart review at each participating site. This study is funded through the NHLBI.
Current Research being done at the EMS Affiliate: The New Mexico EMS Consortium
None at this time.